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Chapter 6 BSE (The spongiform encephalopathies (SEs) (Creutzfeldt-Jakob…
Chapter 6 BSE
The spongiform encephalopathies (SEs)
Creutzfeldt-Jakob disease (CJD)
potential to do with BSE consumers
New variant CJD
similar to BSE cows
memory loss
confusion
mood changes
walking difficulty
loss of coordination
incubation 8 years
early age onset
consumption of BSE
nervous system
lynphatic node
Scrapie
Kuru
Cause
Prions
medium-sized proteins
Mis-shaped one
(PrPsc)
water-insoluble
bunch each other(conglomerates)
β-pleated sheet
original
(PrPc)
α-helix
eating PrPsc containing food
cow's intestine
migrates via lymphatic system and spinal cord to cow's brain
induce brain's PrPc change
(reform/ reshape)
Symptoms
Brain change
aggression
unable to stand etc.
arrival at brain where control mood
depends on physical location of damaged brain
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