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Pharmacokinetics (Distribution (Compartments (Intracellular water (~35%),…

- - - - CYP2
      - CYP3
      - CYP1
  - - - Glucuronidation
      - Sulphation
      - Glutathione addition
      - Glycine / water conjugation
      - Methylation
- - - - Solute carriers (SLC)
        
        Requires concentration gradient
        
        Organic Anion Transporter (OAT)
        
        Organic Cation Transporter (OCT)
      - ATP-binding cassette (ABC)
        
        P-glycoproteins
        
        Transport against concentration gradients
    - - Partition coefficient
      - Ionization
        
        Henderson-Hasselbach equation
        
        Protonation
        
        Weak acid
        
        Removes charge
        
        Weak base
        
        Adds charge
        
        Ion trapping
- - - - Active tubular secretion
        
        Transport via carriers
        
        OAT
        
        OCT
      - Passive diffusion across tubular epithelium
      - Glomerular filtration
        
        Molecules < 5,000-15,000
    - - Saliva
      - Tears
      - Sweat
      - Breast milk
      - Breath
      - Feces