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Urogenital System (Origins (intermediate mesoderm, image, while the…

- - - - ureteric bud invades metanephrogenic mesenchyme forming the renal pelvis
        
        pelvis expands into major and minor calyxes, which grow into collecting tubules
        
        each collecting tubule has a glomerulus at its end; glomerulus originates from metanephrogenic mesenchyme; collecting tubules from the ureteric bud
- - - - SRY activates transcription of Sox9, which inhibits the master TF involved in female development; DAX1 in female development inhibits Sox9; leads to formation of testes
      - WNT4 is master TF involved in female development; activates transcription of DAX1, which inhibits Sox9 expression; leads to formation of ovaries
- - - - metanephrogenic mesenchyme also secretes GDNF; when this ligand binds its Ret receptor (which is present in higher concentrations on the ends of the collecting tubules) it stimulates growth of the collecting tubule