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NS 48 - Anxiolytics, antidepressants, antipsychotics 1 (iii)…
NS 48 - Anxiolytics, antidepressants, antipsychotics 1 (iii)
NTs in Anxiety
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GABA
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benzodiazepines increase GABA in amygdala (less effective in PAG, hence larger doses for panic disorders)
5HT
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Graeff-Deakin hypothesis
5HT is anxiogenic in limbic system + forebrain, but anxiolytic in PAG (oversimplification)
SSRIs: pharmacological affects immediate, anxiolytic effect effects delayed (lag phase)
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Benzodiazepines
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acute anxiolytic effect (no lag phase), decrease muscle tone
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SEs = drowsiness, confusion, amnesia, impaired coordination (be careful driving), withdrawal symptoms
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used to be 1st line, now proven ineffective in longterm
Buspirone
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SEs: nausea, dizziness, headache, restlessness
no sedation, motor incoordination, withdrawal symptoms, tolerance
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