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Wright v4, Complement (Classical pathway, Terminal pathway, Alternative…

- - - - Intestinal immunity
        
        Transcytosis
- - - - PAMPs
      - CLRs
      - NLRs
      - RLRs
      - TLRs
      - DAMPs
        
        sterile inflammation
  - - - iNOS
      - COX2
    - - Vasodilation
        
        Extravasation
        
        Leukocyte trafficking
        
        Activation
        
        Firm adhesion
        
        Rolling
        
        Diapedesis
        
        High endothelial venule
        
        Lymph node
        
        Neutrophil (PMN) migration
        
        post-capillary venule
- - - - IgA
        
        Bodily secretions...mucosa
      - IgG
        
        Circulation
      - IgD
        
        Circulation
        
        class switch recombination
      - IgE
        
        GI and respiratory tracts
        
        Mast cells and basophils
        
        Histamine release
        
        Inflammation
        
        Allergic response
      - IgM
        
        surface of B-cells
      - Antibody effector functions
        
        Opsonization
        
        ADCC
        
        Agglutination
        
        Degranulation
        
        Neutralization
        
        Complement activation
    - - T-independent B-cell response
      - T-dependent B-cell response
  - - - endogneous presentation
  - - - Clonal selection
      - Immunity vs. tolerance
        
        Immunity
        
        Autoimmunity
        
        Systemic
        
        Organ-specific
        
        Hypersensitivity
        
        Type I
        
        Type II
        
        Type III
        
        Type IV
        
        Organ transplant rejection
        
        Tolerance
        
        Immunodeficiency
        
        Cancer
        
        Central
        
        Peripheral
        
        Microbiome
        
        Commensal organisms
- - - - Antigen presentation
    - - Adjuvants
      - Isotype switching
      - AID
      - Somatic hypermutation
      - Germinal centers
  - - - Treg
      - Tfh
      - Th17
      - Th2
      - Th1
      - Memory T-cells
        
        Secondary response
      - Important cytokines
        
        Hematopoietins
        
        Various function
        
        Interleukin-1
        
        Inflammatory mediators
        
        Tumor necrosis factors
        
        Immune system development, effector functions, homeostasis
        
        Interferons
        
        Antiviral response, modulate immune response
        
        Interleukin-17
        
        Pro-inflammatory ... promote neutrophil accumulation and activation
    - - Licensing
      - Perforins/granzymes
      - Fas/FasL
      - Lineage commitment
    - - MHC I
        
        Endogenous antigen presentation
        
        Intracellular antigen
        
        Self vs. foreign peptide
- - - - DC licensing
        
        CD40/40L
- - - - Positive selection
        
        Lineage commitment
      - Central tolerance
      - AIRE