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Necrosis (Coagulative necrosis (cause (heavy metal poisoning, irradiation,…
Necrosis
Coagulative necrosis
cause
heavy metal poisoning
irradiation
ischemia
seen in
heart
Kidney
spleen
Intracellular acidosis
denaturation and coagulation of structural and enzymatic protein
Liquefaction necrosis
Cause
Ischemia
bacterial infection
Features
Microscopic
Structureless tissue debris due to loss cellular architecture
Neutrophils
Gross
hole/gap filled with fluid
seen in
Lungs
Brain
Caseous necrosis
combination of Coagulative and Liquefaction
with firm consistency
Features
Gross
Yellowish white
cheese-like
apperence
Microscopic
Granuloma
Langhan's giant cells
T helper cells
Epitheloid cells
Eosinophilic
Cause
Bacterial infection
E.g: Mycobacterium tuberculosis
fungal infection
E.g: histoplasmosis
Fat necrosis
seen in
Pancreas
Acute pancreatitis
Breast
Traumatic fat injury
Focal area of fat destruction
Lipase enzymes released from pancreas
break TAG into fatty acids
FA combines with Ca2+ process called saponification
forms chalky white
Features
Gross
chalky white calcium deposits
Microscopic
Pale outlines of necrotic fat cells
basophilic staining
hematoxylin stains calcium blue
Fibrinoid necrosis
immunologic injury
Feature
microscopic
Fibrinoid material that has smudgy pink (eosinophilic) appearance
Pink staining of fibrin link proteinaceous material
Gangrenous necrosis
in lower limbs and bowel due to loss of blood supply
types
Dry
Coagulative necrosis without liquefaction
mummified apperance
frostbite injury
Wet
superimposed bacterial infection
liquefactive necrosis