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Follicular Lymphoma (Distinguishing Feat. (Differs from reactive…
Follicular Lymphoma
Distinguishing Feat.
Differs from reactive follicular hyperplasia by...
FL
disrupts normal lymph node architecture
(follicular hyperplasia)
FL
lacks tingible body macrophages
in germinal centers
FL
expresses Bcl2
in follicles
FL is
monoclonal
(reactive process would be polyclonal)
Cells
Small
B Cells (
CD20+
)
Form
follicle-like nodules
t(14;18)
-- BCL2-Ig Heavy Chain Locus --> overexpress BCL2 -->
apoptosis inhibited
BCL2-Ig Heavy Chain
Treatment
Only for
symptomatic pts
Low-dose chemo
Rituximab
(anti-CD20 ab)
Clinical Feat.
Presents in adulthood
Painless lymphadenopathy
Complications
Progression
to
diffuse large B-cell lymphoma
(presents as enlarging node)