Please enable JavaScript.
Coggle requires JavaScript to display documents.
Specific immunity: adaptive immunity (antibody mediated (B-cell) (B-cell…
Specific immunity: adaptive immunity
cell-mediated (T-cell)
T cytotoxic cells
(contain a TCR receptor and CD8)
target:
endogenous antigens (non-self cells from a transplanted organ, mutated (cancerous)/infected cells
signal:
human cell with a MHC I complex displaying the abnormal peptide flag
T helper cells
(contain a TCR receptor and CD4)
signal:
cell (antigen presenting cell) presenting a fragment of an exogenous antigen on its MHC II complex
what the MHC II presents matters, this will determine if an immune response is necessary
target:
exogenous antigens (invaders, that are not human cells)
anti
b
ody mediated (B-cell)
this is the body's pathway for generating antibodies
B-cells themselves do not create antibodies
B-cell activation
T helper cells (with help from CD4) need to recognize the specific antigen and activate the B-cell
B cells differentiate into plasma cells and B-memory cells
once a soluble antigen binds to a plasma membrane bound receptor in the B-cell it presents a fragment of the antigen on its MHC II
if B-memory cells ever see that antigen again they will differentiate (into plasma cells) and proliferate
plasma cells = produce antibodies
Why do we need both?
components of specific immunity
antigen needs to be presented to T cells and B cells (Ag is presented by either
MHC I
or
MHC II
)
antigen needs to be recognized
CD: cluster of differentiation markers (accessory molecules on T cells that serve both structurally and functionally in TCR-MHC interactions)
CD8
: mediates MHC I and T cytotoxic interaction
CD4:
mediates MCH II and T helper interaction
these define the effector function and MHC restriction of a T cell
they bind to the MHC molecules at a different site from the TCR and form an important part of the TCR complex
they are a safety checkpoint