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Chronic Lymphocytic Leukemia (CLL) (Stages (3 (Hb <11, B/o too much CLL…
Chronic Lymphocytic Leukemia (CLL)
Cells
Naive B-Cells
: CD
5
& CD
20
Smear:
Smudge Cells
Treatment
Variations
Lymph node involvement --> generalized LAD -->
"small lymphocytic lymphoma"
Complications
Hypogammaglobulinemia
:
Infection = most common cause of death
Autoimmune Hemolytic Anemia
: Ig produced by cancerous cells self-reactive w/ normal tissues
Transformation to diffuse large B-cell lymphoma (Richter Transformation)
: clinical marker = enlarging node/spleen
Immune mediated thrombocytopenia
Stages
1
2
3
Hb <11
B/o too much CLL in BM
4
Platelets <100
B/o too much CLL in BM
0
All stages have leukocytosis w/ lymphocytosis >5K