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Non-steroidal anti-inflammatory drugs : aspirin & paracetamol Non…

- - - - by blockade of cyclooxygenase
  - - - typically reduce pain associated with inflammation and tissue damage
      - Traumatic pain
      - Postoperative apin
      - Arthritic pain
      - Dental pain
      - Pain in bleeding
    - - No effect on normal body temperature and hyperthermia
    - - Arthritis (gout)
      - Myostasis
      - RA
      - Tendovaginitis
- - - - e.g Hastric mucosa, kidney, platelet, endothelium
- - - - meloxicam
      - nabumetone
      - nimesulide
      - ectodolac
- - - - Via COX2 inhibition
        
        induced by inflammation or tissue trauma
      - Prevention of nociceptor sensitizing effect of PGE2 & PGI2
    - - Via COX2 inhibition
        
        via dorsal horn of spinal cord
        
        prevention of the sensitizing effect of PGE2 on nociceptic spinal neurons
  - - - Il-1beta, TNF-alpha
        
        PGE2 release in hypothalamus -> elevation of the set point
  - - - PGE2 and PGI2 causes vasodilation and potentiate the plasma extravasation effect of histamine bradykinin, bu the cellular phase of inflammation may be even stimulated by NSAID
- - - - COX-1 and -2 inhibition
        
        hypertension
        
        HT
    - - COX-1 < -2 inhibition
      - edema
      - hypertension
      - HT
    - - Diminisehd renal function w/ decreased GFR
        
        by reducing TXA2 synthesis in platelets
        
        only for aspirin
      - premature closure of the ductus arteriosus
- - - - Hypovoleamia
      - HT
      - liver cirrhosis
- - - - icnreased gastric damage
    - - bleeding
    - - reduced efficacy owing to water retention
    - - Hyperkalemia