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**MUSCLE CONTRACTION (SMOOTH (:heavy_minus_sign: T-Tubules, :arrow_down:…

- - - - ATP
        
        RIGOR MORTIS
      - [Ca2+]
        
        TROPONIN
        
        Binding sites
        
        T : TROPOMYOSIN
        
        I : ACTIN
        
        C: Ca2+
        
        Channels: direct mechanical connection
        
        Voltage-gated Ca2+
        
        On membrane
        
        Ca2+ release channels
        
        On SRs
    - - Molecular
        
        Actin :heavy_plus_sign: Myosin Crosslinks
        
        Optimal cross linking
        
        Sliding Filament Model
        
        1. ADP + P1 + Ca2+
        
        CONTACT
        
        ADP + Ca2+ -Pi
        
        POWER STROKE
        
        3. + ATP
        
        RELEASE
        
        4. Hydrolyzation -> ADP + Pi
        
        REPOSITION
      - Physiological
        
        Types of Contraction
        
        Isometric
        
        Same length
        
        Increased tension
        
        Isotonic
        
        Same weight
        
        Contraction/shortening
        
        Max load
        
        All cross bridges on board just to hold the weight, can't pull/move
        
        Feedback
        
        **Muscle spindle, Intrafusal
        
        Report length & stretch
        
        Shorten when muscle contracts
        
        Golgi organ tendon
        
        Report force
        
        Summation
        
        TEMPORAL
        
        accumulation of [Ca2+]
        
        MAX contraction
        
        TETANUS
        
        SPATIAL
        
        Recruitment of MOTORUNITS
        
        Motor neuron :heavy_plus_sign: muscle fibers
  - - - :arrow_forward: Sarcomere
        
        :arrow_forward: Myofibril
        
        :arrow_forward: fibers