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BLOOD (plasma (proteins (Globulins, Fibrinogen, ALBUMIN, clotting factors…

- - - - granulocyte
        
        most rare
    - - granulocyte
        
        pink/red cytoplasm
    - - agranulocyte
        
        huge macrophages
    - - agranulocyte
        
        B-cell
        
        T-cell
        
        NKC
    - - granulocyte
        
        segmented nucleus
  - - - Platelets
        
        alpha granule = adhesion factors; chemokines
        
        delta granule = aggregation; ADP, Ca2+ cofactor
      - Coagulation cascade
        
        series of enzymatic rxns to create THROMBIN
        
        thrombin will convert fibrinogen to fibrin
        
        fibrin is the glue that hols platelets together in a clump
      - endothelial cells
        
        normal resting state
        
        anti-thrombolytic properties
        
        injured state
        
        prothrombolytic properties
    - - secrete aggregations factors
      - aggregation
      - adhesion to von willebrand factors via Glycoprotien Ib receptor (GpIB)
  - - - 4xHeme
        
        abnormal: carboxyhemoglobin, methemoglobin, sulfhemoglobin
      - 4xGlobin
        
        abnormal: Thalassemias, hemoglobinopathies (sickle cell)
    - - glycolysis
      - methemobolin shunt
      - hexose monophosphate shunt
      - Leubering-Rapaport shunt
    - - Permeable
        
        water/electrolyte/gas exchange
      - Stackable and deformable
        
        to pass thru microvessels
      - SA maximized