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IgE-mediated Anaphylaxis Overview (Symptoms (Fatal anaphylaxis (Associated…
IgE-mediated Anaphylaxis Overview
Symptoms
Difficulty talking/hoarse voice or cry
Persistent cough
Swelling/tightness in throat
Dizziness/collapse
Tongue swelling
Difficult or noisy breathin
Infants can go pale & floppy
Fatal anaphylaxis
Associated with:
Upright posture during episode
Co-existing asthma
Delayed or no adrenaline
Those w high risk:
Teenagers/young adults - risk taking behaviour
Eating away from home
Peanut and tree nut accounts for 85% of fatal food anaphylaxis
Stats for fatal anaphylaxis
In 15 yrs
10% inc
10% inc in food related anaphylaxis hospital admission
23 deaths
Contrast to USA/UK where deaths/hospitalizations are decreasing
Triggers
Wheat
Fish/shellfish
Soy
Other foods- beef, chicken, pork, legumes, watermelon, kiwi fruit
Tree nuts
Peanuts
CMPA
Egg
Management
Avoid food triggers
May result in E & Pro deficiencies, needs DTN attention
Epipen
How it happens
Symptoms occur within minutes to hr
Allergens bind to IgE antibody on mast cell
Causes mast cell to release histamine and other inflammatory mediators
Non IgE mediated food allergy does not involve IgE