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Causes of chronic diarrhea (Dysmotility -> rapid transit time may be…
Causes of chronic diarrhea
Inflammatory-> cytokines release -> stool pus or WBC-related proteins eg calprotectin
Idiopathic inflammatory bowel disease
Crohn's disease, UC
uveitis, polyarthralgias, PSC, erythema nodosum, pyodrma gangrenosum
Microscopic colitis
Types
Lymphocytic colitis
Collagenous co;itis
Risk
Mddle age W
Drugs
NSAID
Statins
PPI
SSRI
Immunodeficiency -> prolonged infectious diarrhea, usu giardiasis, sprue bac overgrowth
Selective IgA deficiency, common variable hypogammaglobulinemia
Eos GE
Cbarcot-Leiden crystals in stool, peripheral eosinophilia (50~75%)
Other
Radiation enterocolitis
Chronic GVHD
Behcet's syndrome
Cronchite-Canada syndrome
Dysmotility -> rapid transit time may be the cause of other etiologies, basically primary motility problem is uncommon
Hyperthyroidism
Carcinoid syndromes
Drugs
Prokinetics
PG
Primary visceral neuromyopathies / idiopathic acquired intestinal pseudo-obstruction -> stasis -> bac overgrowth
Diabetic diarrhea
Irritable bowel syndrome cb disturbance of intestinal and colonic response to various stimuli
Factitious causes (15% of unexplained diarrhea)
Munchausen syn
Eating disorders