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cartilage and bone disease. FIRST AID 426 - clinical correlate…
cartilage and bone disease. FIRST AID 426 - clinical correlate
DEGENERATIVE
Osteoporosis
normal bone mineralization - Ca and PO
(++) bone resorption due to - estrogen
2dary to drugs
medical conditions
Dx: Bone mineral density scan - T-score ≤2.5
Fragility fx of hip or vertebra
Trabecular and cortical bone lose
osteoathritis
CONGENITAL
Osteopetrosis "Marble bone disease"
Defective osteoclasts - mutations impair them to create acidic environment
thickened, dense bones prone to fracture
Bone fills narrow space
cranial nerve compression and palsies - narrowed foramina
Treatment - bone marrow transplant
Xray - bone-in-bone appearance
osteitis deformans / Paget disease of Bone
common, localized
(++) osteoclastic activity -> (++) osteoblastic activity
increased hat size
hearing loss
(++) risk of osteogenic sarcoma
chalk-stick fx
high output heart failure
METABOLISM
Osteomalacia/Rickets
defective mineralization of osteoid or cartilaginous growth plates - vit D -
epiphyseal widening
bow legs in children
chraniotabes
rachitic rosary
metaphyseal cupping/fraying
Vascular
Avascular necrosis
infarction of bone and BM
medial circumflex femoral artery
CAST Bent LEGS
INFLAMMATORY
Rheumatoid Arthritis
Gout
Sjögren
Septic arthritis
seronegative spondyloarthritis
Lupus
sarcoidosis