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Extracellular matrix (Glycoproteins (Laminin (Basement membrane component,…

- - - - interactions of cells w/matrix. Binds to:
        
        Blood stream: Blood clotting, wound healing, phagocitosis of bacteria
        
        Collagen
        
        Other matrix components
        
        Cell surface receptors
  - - - Ehlers-Danlos Syndrome
        
        prevents conversion of procoll-> tropocoll
        
        collagen and lysine hydroxylase gene mutations
      - Osteogenesis imperfecta
        
        Type I collagen associated gen mutation
      - Scurvy
        
        Reduced hydroxylation due to Vit C def.
    - - Basal lamina
    - - BV, stroma network in immune organs, BM organ capsules, liver, reticular fibers etc
        
        PAS and Silver salts
    - - Cartilague, IV discs, vitreous body of the eye
    - - skin, tendon ligaments, bone and cornea
  - - - Marfan sd
        
        fibrilin gene mutation on chromosome 15
        
        CV defects
        
        skeletal defects
        
        ocular defects
      - skin, walls of BV - Arteries, lungs
- - - - PGs aggregates + water = GEL MATRIX
        
        Resist compressive forces
        
        Diffusion of soluble water compounds
        
        Ions
        
        Nutrients
        
        Metabolites
        
        Growth factors
        
        Hormones