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connective tissue (Support cells: permanent/resident (Myofibroblasts…
connective tissue
Support cells: permanent/resident
Myofibroblasts
Derived from fibroblasts ?
contain actin microfilaments + myosin thick filaments
intrinsic ability of cell contraction
Osteoblasts
Type I collagen + osteoid
Fibroblasts, fibrocytes
Principal collagen producers
collagen fibers organization
Adipocytes
unilocular fat - adults
multilocular fat - fetuses and neonates
chondroblasts
Type II collagenin cartilague
Specialized
Cartilage
Bone
Adipose
Bone marrow
Extracellular matrix
fibrillar proteins
Collagen
Elastic fibers
Elastin
Fibrillin
Fibronectin
Proteoglycans
Glycoproteins
Dense CT
Regular
highly ordered - large parallel bundles
tendons
bone
cornea
Irregular
Dermis and capsules
fibers > cells
Guest cells
Macrophages
Derived from bone marrow monocytes
Can remain in tissues for long periods
Kupffer cells
Osteoclasts
Microglia
Alveolar macrophages
Antigen-presenting cell - locally or distant
Morphologically similar to fibroblasts
Mast cells
Large membrane-bound granules of inflammatory mediators
Early role in response to tissue injury
Type I HS
Loose CT
irregular array of its fibrillar protein matrix
Submucosa of may organs
papillary dermis of the skin
Transient cells
migrate into CT from the blood stream: Ly, plasma cells, NEU, BA, MO.
Basal lamina
Meshwork-like > type IV collagen + heparan sulfate + laminin
provides support to parenchymal cells that carry out the specific tissue and organ functions