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Hypothalamus (Polypeptide Hormones # # (Thyrotropin RH, Gonadotropin RH,…
Hypothalamus
Polypeptide Hormones
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Thyrotropin RH
Gonadotropin RH
Corticotropin RH
Growth HRH
Growth HIH/Somatostatin
Hypothalamic-Hypophysial Portal System
ANTERIOR PITUITARY AKA ADENOHYPOPHYSIS
Corticotropes
ACTH/Corticotropin
Adrenal Cortex See MAP
Zona Reticularis small effect
Androgens
Zona fasciculata Most effects
Cortisol
Inhibits Immune System
Reduce Inflammation
gluconeogenesis
Glucose
Protein
Lipid
Thyrotrope
TSH AKA Thyrotropin, see Thyroid Map
Somatotropes
GH
Boost transcription & RNA translation
Promotes protein depositation
increase insulin resistance
Decrease Carb use
fat use
Excess
Gigantism if young
Acromegaly
fat deposits in liver
Cyclic Feedback Loop
decreases with age
30-40% of AP
Gonadotropes
FSH
Female-egg release
Male Sertoli Cells
Sperm
LH
Ovaries
Progesterone
Making Milk Machinery
Uterine Secretions
Estrogen
Positive Feedback with LH
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Ovulation
Testes Lehdig Cells
Testosterone
Lactotropes
Prolactin
Milk secretion
Breast Development
Prolactinoma-benign
Layer 1 syntheses layer 2 which is stored
supraoptic & ventricular neclei
Osmoreceptors
shrink in dehydration trigger ADH exocytosis
ADH
Oxytocin
axon to PP capillaries
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Posterior Pituitary AKA Neurohypophysis
Storage after anterograde transport
Oxytocin
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Pitocin synthetic version
Stop bleeding
Uterine Contraction
Milk from alveoli to ducts
ADH/Vasopressin
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increase BP
Vasoconstriction
Pituicytes
Glial-like supporting cells
Amino-Tyrosine Hormone
Dopamine/Prolactin Inhibiting Factor