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Advanced (Th (knjiga 2 (knjiga 4 ((analiza (1-3 +LČ), iz 2005, 42000, 78…

- - - - od 1970 do 2000
        
        EBCTCG - FEC/FAC vs CMF - DFS 11%, OS 16%
      - od 2000 do danas
        
        CALGB 9344, E1199, B27
        
        BCIRG 001, 1500 pts, FAC vs TAC, LC poz, DFS 75vs68 SS, OS HR 0.70
      - DD
        
        C9741, OS HR.85 nSS
        
        Italijanska, EC+/-5FU 2 ili 3 tj, DFS slican 9741, 5y OS 94 vs 89 HR 0.65 SS
        
        meta analiza, >17000 pts, DFS HR 0.84, OS HR 0.86- SS, subanaliza ER neg HR 0.80, ER poz HR 0.93nSS
        
        GIM2
        
        https://www.ncbi.nlm.nih.gov/pubmed/25740286
      - TC vs AC - US studija, st I te II, 4 ckl, 7y DFS hr 0.74, OS HR 0.69- SS
      - TNBC
        
        MD Anderson, >1000 pts, TNBC vs non TNBC, neo KT, pCR 22vs 11%
        
        Platinum, samo u trailsima
        
        Silver, 28 pts, PCR 22%
        
        u tijeku
        
        CALGB 40603, neo, Carbo + TAC
        
        Triple negative trial, meta, Carbo vs Doc
        
        PARP
  - - - knjiga 5
        
        RNI
        
        presjek studija
        
        http://sci-hub.tw/10.1016/j.ijrobp.2017.10.036
        
        studije
        
        M20
        
        EORTC 22922, centar/medijalno ili ext+LC poz, DFS 78vs75% SS, nSS OS 83vs80 - 10y
        
        OTOASOR
        
        3 more items...
        
        ALTO
        
        1 more item...
        
        PMRT, T3N0, mastektomija
        
        Tagian, 313 pts
        
        Floyd
        
        3 studije
        
        Whelan (PMRT, LN poz), 1800 pts, 10y DFS 82%vs77% SS, OS nSS 83vs82%
        
        EORTC 22922, centar/medijalno ili ext+LC poz, DFS 78vs75% SS, nSS OS 83vs80 - 10y
        
        meta analiza, OS SS (HR 0.88 - mal benefit, ukupno 1.6%)
      - iz 2005, 42000, 78 studija
        
        analiza
        
        1-3 +LČ
      - IMRT vs (2d, 3D)
        
        Royal Marsden
        
        Pignol
      - API kozmetički reziltst
        
        RAPIDO
      - sek tumor, WECARE
      - kardijalna toxičnost, Darby
  - - - NEOADJUVATNO
        
        studije
        
        sve
        
        https://www.google.ba/search?q=bevacizumab+neoadjuvant+therapy+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjkmZHy1enaAhWSw6YKHW_HDmkQ_AUICigB&biw=1229&bih=548#imgrc=vFSqfBLvDj4L-M:
        
        GEPAR qUINTO
        
        Qinto
        
        aRTEMESIS
        
        CALGB 40603, neo, Carbo + TAC
        
        B40, neo/adj
      - ADJUVATNO
        
        Beatrice
        
        https://www.google.ba/search?q=bevacizumab+adjuvant+therapy+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwjMnOXw1unaAhUDMZoKHfXEB7EQ_AUICigB&biw=1229&bih=548#imgrc=CkE8HlaegyDi4M:
        
        BETH
        
        https://www.medscape.com/viewarticle/817707
    - - CDK 4/6
        
        palbo
        
        PENELOPE
        
        https://www.youtube.com/watch?v=Djw1PmpZt9w
      - HT
        
        mix HR+, HER poz
        
        B52
        
        https://www.youtube.com/watch?v=hiOrrfxes34
        
        AI vs Tam
        
        IMPACT
        
        PROACT
        
        AI vs AI
        
        ACOSOG-ova studija u tijeku
        
        triple pozitivna HER+HR+
        
        studije
        
        Tra+Lapa
        
        Letr
        
        TbcRC 006-12 tj
        
        1 more item...
        
        TbcRC 023-24 tj
        
        2 more items...
        
        Letro ili Tamox
        
        PAMELA
        
        2 more items...
        
        Tra+Per
        
        Ful+Palbo
        
        NA-PHER
        
        Letro
        
        Per Elisa
        
        2 more items...
        
        Trasvs TDMvs TDM1+ET
        
        ADAPT
        
        biomarker
        
        1 more item...
      - HER poz
        
        Trastuzumab
        
        NOAHAC+CMF+Trast
        
        https://www.youtube.com/watch?v=_OSaJE2rqxU
        
        https://www.ncbi.nlm.nih.gov/pubmed/20113825
        
        TECHNO, EC+P+Trast, neod, pCT22.6
        
        https://www.ncbi.nlm.nih.gov/pubmed/21788566
        
        Pertuzumab
        
        TRYPHENA
        
        https://www.youtube.com/watch?v=Nf4gZU3cU3U
        
        https://www.ncbi.nlm.nih.gov/pubmed/23704196
        
        Neosphere
        
        https://www.youtube.com/watch?v=R_w4HYXuo9M
        
        studija
        
        dizajn
        
        https://www.google.ba/search?biw=1229&bih=548&tbm=isch&sa=1&ei=TxjrWpywMYOb6ATc2aiwAQ&q=neosphere+study&oq=neosphere+study&gs_l=psy-ab.3...2015.3382.0.3582.6.6.0.0.0.0.277.994.0j2j3.5.0....0...1c.1.64.psy-ab..1.2.521...0i19k1j0i30i19k1j0i5i30i19k1j0i13i30i19k1.0.a47P7IP_j3Q#imgrc=FRv8RXymXp7KZM:
        
        rezultati
        
        https://www.google.ba/search?biw=1229&bih=548&tbm=isch&sa=1&ei=TxjrWpywMYOb6ATc2aiwAQ&q=neosphere+results&oq=neosphere+results&gs_l=psy-ab.3...844.2673.0.2798.8.8.0.0.0.0.128.260.1j2.3.0....0...1c.1.64.psy-ab..5.1.14...0i19k1j0i30i19k1j0i5i30i19k1.0.05UC0KoKP4o#imgrc=H-br52A7l0gCcM:
        
        studije
        
        https://www.google.ba/search?q=pertuzumab+neoadjuvant+study&source=lnms&tbm=isch&sa=X&ved=0ahUKEwiJ6u3R2-naAhUHQJoKHbQcCvoQ_AUICigB&biw=1229&bih=548#imgrc=ZnOOmUXuuK0UqM:
        
        Lapatinib
        
        US Oncology
        
        https://edition.cnn.com/videos/us/2018/02/14/shaun-white-olympic-american-flag-sot.cnn
        
        CHER-LOB
        
        https://www.youtube.com/watch?v=5Uu3kCEEc98
        
        B41
        
        neo ALTO
        
        https://www.youtube.com/watch?v=Y-33-z7T8so
        
        http://theoncologist.alphamedpress.org/content/20/4/337/T1.expansion.html
        
        TDM1
        
        ADAPT
        
        https://www.youtube.com/watch?v=a00esZ3B-aQ
        
        https://www.ncbi.nlm.nih.gov/pubmed/28682681
        
        https://www.google.ba/search?q=adapt+study+breast+cancer&source=lnms&tbm=isch&sa=X&ved=0ahUKEwik8frF3unaAhXCK5oKHYzGCk4Q_AUICigB&biw=1229&bih=548#imgrc=OR6Sfzgst2YlKM:
        
        KRISTINE
        
        https://www.ncbi.nlm.nih.gov/pubmed/29175149
        
        dizajn
        
        https://www.google.ba/search?q=tdm1+study+adjuvant+breast&source=lnms&tbm=isch&sa=X&ved=0ahUKEwj-o-_q3enaAhXlO5oKHZeFAHAQ_AUICigB&biw=1229&bih=548#imgrc=h3Eyb9Ax0he2OM:
    - - CALGB 40603, neo, Carbo + TAC
      - Ixabeiolen
        
        pCR (40% vs 35% ACT-T)
        
        https://www.youtube.com/watch?v=COvnHv42T-A
      - Gepar
        
        Qinto
        
        Sixto
        
        GeparSepto, nab vs obični pakli plus EC
      - Neo KT
        
        meta analiza, HR 0.37 za pCR DFS
        
        CTNneoBC, 12000 pts, PCR boji DFS, OS
      - BRCA
        
        Talasoparib
        
        MD, Litton; 20 pts; BRCA+; TN; pCR50%
        
        kombinacije
        
        +
        
        ATR
        
        An inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase,
        
        IT
        
        platinum citostatici
        
        Poljska studija; indirektno Talaso vs Cis; pCR 53vs 60%; cijena 60 000 KM vs 500 kM
    - - B51
    - - korejska studija
        
        CREATEX, 910 pts
        
        neo kt
        
        rez bolet
        
        PFS 74vs67%-5y
        
        +OS 89vs83%
      - EA
        
        u tijeku
        
        basal like Tn
        
        rez bolest
        
        cis vs cape
      - SWOG
        
        rez bolest
        
        TN
        
        adj Pembro
  - - - OlimpiA
        
        http://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/OlympiA-a-randomized-Phase-III-trial-of-olaparib-as-adjuvant-therapy-in-patients-with-high-risk-HER2-negative-breast-cancer-BC-and-a-germline-BRCA1-2-mutation-gBRCAm