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Mezoteliom (Dijagnoza (PHD (sarkomatoidni (loša prognoza), epiteloidni,…

- - - - vlakna
        
        pleura
        
        fagocitoza
        
        plakkarinoza
      - 70-80%
    - - p16, p14, NF2
    - - https://www.google.ba/search?q=mesothelioma+paradigm&source=lnms&tbm=isch&sa=X&ved=0ahUKEwim6uOO8uvaAhVjCZoKHWA_ANAQ_AUICigB&biw=1229&bih=587#imgrc=lvhe6Gwhx_dixM:
  - - - puno genskih mutacija
- - - - th opcije
        
        torakocenteza
        
        talkaža
        
        torakalni dren
      - cito 23% poz
  - - - loša prognoza
  - - - bol
      - nepleur bol
    - - rek izljev
      - pl zadebljanje
- - - - malo bolesnika
    - - EPP
        
        2P, lung plis LČ, diapfragma
        
        <5%
        
        smrtnost4-30%
        
        OS 4-20 mj
      - P/D
        
        kod uznpredovale (lokalne invazije, LČ)
        
        smrtnost 5%
  - - - RT
        
        postop RT
        
        studije
        
        Harvard retrospektiva, CAP (cytoaxa, Adr/cis)+RT+adj kemoth, MS 19 mj
        
        MSKCC
        
        triala
        
        Rusch, MSKCC, f2, MS 34 mj st I-II, kasniji stadiji 10 mj
        
        pal RT
        
        doza 0-40Gy
        
        RT na područje drena
        
        bez smanjenja lokalne invazije kontamncijom s RT
      - sistemska
        
        stanica
        
        kemoth
        
        1L
        
        Vogelzang, 12.9 vs 9.0, HR 0.74, 226 pts
        
        GC
        
        Vino
        
        Peme
        
        VGFR
        
        beva
        
        MAPS
        
        rezultati
        
        1 more item...
        
        2L
        
        Peme (ako nije bio u 1L)
        
        Vino
        
        gem
        
        IT
        
        samo IT
        
        PDL1+CTL4 2L
        
        2L Nivo+Ipi
        
        MAPS2
        
        3 more items...
        
        INITIATE
        
        2 more items...
        
        mOS 11mj
        
        CM 743 N+I vs KT
        
        Durva+Tremelimumab - NIBIT-MESO
        
        dizajn
        
        1 more item...
        
        mOS 16.6mj
        
        mono
        
        CONFIRM u tijeku
        
        Pembro
        
        2L
        
        KN028
        
        mono
        
        1 more item...
        
        CTL4
        
        Magistra vitae
        
        f2 + f3 - 2L
        
        2 more items...
        
        IT+KTvsKT
        
        Durva
        
        https://www.sciencedaily.com/releases/2020/06/200611152457.htm
- - - - Y, KS, WBC<8, sarko