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Timom (općenito (uzrok (nepoznat, eb virus), klinička slika (sy (paraneo,…

- - - - prednji TTT-timom, teratom, terible limfom
  - - - paraneo, stridor
- - - - th predop
- - - - primarna kemoradioterpaija
      - primarna kemoterpaija
        
        vrste kemoterpaije
        
        CAP
        
        PE
        
        VIIP
      - procjena resektabilnosti
    - - Sunitinib (Thymic carcinomas only)7
        
        kod cKIT, <10% ekspresija
      - Everolimus9
        
        50 pts, 6RR (1CR)
        
        https://www.ncbi.nlm.nih.gov/pubmed/29240542
      - Octreotide (including LAR) +/- prednisone12
        
        http://ascopubs.org/doi/full/10.1200/JCO.2004.02.047
        
        ORR12 pts od 50(2CR)
        
        poz oktreoscan
      - pembro
        
        velik RR
        
        velika toksičnost
  - - - medialna sternotomia
  - - - preporuke
        
        WHO G3, RR blizu ili<1mm, gross pleularna adhezija
      - polje
        
        ležište resekcije
        
        involvirani organi
      - adj RT
        
        kontroverzno
        
        Kura, 100p, bolja LC
        
        bez mikro invazije - LC neg ![](https://coggle-
        
        II-III-LC
        
        OS poz
    - - pal-8, 20, 30Gy
      - inop, rez gros bolest
        
        60-70Gy
      - adj 50Gy
      - +RR
        
        54Gy
  - - - citostatici
        
        2L
        
        Pemetrexed8
        
        26 pts, 2PR, 2CR
        
        studija
        
        Paclitaxel10-11
        
        Gemcitabine13
        
        5-FU and leucovorin14
        
        Etoposide4
        
        Ifosfamide15
        
        1L
        
        vrste kemoterpaije
        
        CAP
        
        PE
        
        VIIP
      - Timični karcinom
        
        KT-cis plus adria