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Microfludic study (Advantages (M&N generated together (Primary/…
Microfludic study
Advantages
Microfluidic
Perfusion
M&N generated together
Primary/ functional
Automated
Low cost
Reproducible
External control
Tractible systen
Disadvantages
Inability to customise
Difficult to spatially seperate
May lack glia
Different neuronal types
Incompatibility with some end-point assays
Rationale
New tool to understand critical aspects of NMJ function in disease
Support with what muscle-nerve cells have been used to do.