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infection drugs (antibacterials (inhibition of protein synthesis by…

- - - - inhibits peptidoglycan polymerization, resulting in inhibition of bacterial cell wall synthesis and cell death.
    - - gram positive aerobic organisms
      - bactericidal - penicillin G inhibits of cell wall synthesis by binding to penicillin binding proteins (PBPs).
  - - - inhibits bacterial synthesis of dihydrofolic acid by competing with PABA for binding to dihydrofolate synthetase
      - bacteriostatic
  - - - inhibition of DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair,
- - - - a synthetic allylamine antifungal
      - nhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway.
    - - An imidazole derivative
      - inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes
    - - interacts with 14-alpha demethylase an enzyme that converts lanosterol to ergosterol, inhibiting ergosterol synthesis.
    - - a morpholine antifungal drug that inhibits Δ¹⁴-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes
  - - - antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis
- - - - A pyrethroid insecticide
      - active against a broad range of pests
      - acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated = paralysis
    - - an irreversible cholinesterase inhibitor
      - also treats lice
    - - a broad-spectrum anti-parasite medication
      - oral
      - group - Avermectin
      - binds selectively and with high affinity to glutamate-gated chloride ion channels causing an increase in the permeability of the cell membrane to chloride ions resulting in hyperpolarization of the cell --> paralysis + death of the parasite.
  - - - 12mg PO
    - - 400mg/day 3-5 days PO
      - benzimidazole broad-spectrum anthelmintic
      - inhibitory effect on tubulin polymerization which results in the loss of cytoplasmic microtubules.
- - - - A guanosine analog antiviral drug that acts as an antimetabolite
      - herpes zoster (shingles), genital herpes, and chickenpox.
      - Competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by acting as a chain terminator.