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Primary sclerosing cholangitis (clinical (history (jaundice, pruritis, RUQ…
Primary sclerosing cholangitis
defintion
biliary disease of unknown etiology characterised by inflammation and fibrosis of intra and extra-heaptic bile ducts
aetiology
?
associations
UC
crohns (less so)
HIV
incidence
pathophysiology
clinical
history
jaundice
pruritis
RUQ pain
fatigue
examination
diagnosis
ERCO
ancillary
bloods
ANCA +ve
?liver biopsy - limited role
complications
cholangiocarcinoma
increased risk colorectal cancer
treatment