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Arthritis (Rheumatoid Arthritis (refractory RA (abatacept (Ig fusion…

- - - - Ig fusion protein that binds to antigen presenting cell
        prevent costimulatory signals required for Tcell activation
        
        SE: ROI
    - - binds cyclophilin
        complex inhibit calcineurin
        intend to suppress function and replication of T cell
        
        SE:
        renal toxicity
        DM
        HTN
        facial dysmorphology
        risk of infection
  - - - SE: ROI
  - - - SE: ROI
  - - - SE: ROI
  - - - SE: ROI
  - - - SE: ROI
- - - - SE:
        Constipation
        Respiratory Depression