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Gout (Acute (Reversible, Non selective COX inhibitor Inhibit re…
Gout
Acute
Reversible, Non selective COX inhibitor
Inhibit re-absorption of uric acid in kidney
Phenylbutazone
SE:
Bleeding
Peptic Ulcer
prevent microtubule assemby
prevent replication of inflammatory cells
colchicine
SE:
Bone marrow injury
Kidney and liver injury
Chronic
Inhibit reabsorption in kidney
Allopurinol
Febuxostat
inhibit xanthine oxidase
inhibit synthesis of uric acid
Probenecid
Sulfinpyrazone
Severe Chronic
Recombinant Uricase
Metabolise Uric Acid to Allantoin
Pegloticase
Unresponsive
Glucocorticoid Receptor Agonists
Prednisone
Methylprednisolone
inhibit synthesis of prostaglandin
inhibit production of inflammatory cytokine
inhibit expression of NFkB
kill proliferating immune cells
SE:
Osteoporesis
Easy brusing
Poor Wound Healing
Thin Skin
Hyperglycemia
Truncal Obesity
Moon Facies
Buffalo Hump