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Non-lethal apoptosis (Spatial gating (IAP family as regulators (Mito…
Non-lethal apoptosis
Spatial gating
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PTM
Phosphorylation can inhibit, gradients of kinases
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Mitochondria
BAX/BAD inhibit BCl2 family leads to mPTP and cytC release apoptosome, caspase 9 cleavage then caspase 3 activity which cleaves targets.
The sequence of events above can change because in some settings non-lethal apoptosis does not involve mPTP yet mitochondria are closely involved.
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