Hyaluronic acid deposition in interstitium. Non-pitting edema. Hypothyroidism (Myxoedema), Graves (Pretibial Myxoedema)
Hypo: Fatigue, Cold intolerance, Dry skin, Constipation, Weight gain, Coarse hair
Hyper: Heat intolerance, Weight loss, Dyspnea, Palpitations, Anxiety, ↑Freq of bowel movements, Afib, Eyelid retraction/lag, Goiter, Diaphoresis.