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PARKINSON (a dementia prevalence of about 25% among patients with PD…
PARKINSON
The most common dementias associ-
ated with movement disorders are PDD, DLB, CBD (corticobasal degeneration) e PSP (progressive supranuclear palsy)
They are grouped in synucleinopathies (DLB e PDD) e taupathies (CBD e PSP)
Ser Parkinson 200 ye ago descrived people with tremor, difficult in walking, non reactive looking face
In PD in midbrain there's the absence of pigmented cells that producte dopamine in substantia nigra e ventral tegmental area
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nonmotor symptoms
- mood
- motivational
- cognitive disorders
progressive and impair quality of life
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As well as depression this disorders include
- apathy
- impulse control (pathological gambling, hiposexuality)
- deficit in EF such as shifting, attention, WM
- ep memory
Study:
PD show increase in prevalence of depression, anxiety, apathy, hallucinations, cognitive changes, sadness
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There are structures modulating dopamine sistem, but the problem is in the production of dopamine and flux, not in the structures
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- in addiction to dopaminergic drugs improving PD motor functions, they can also improve motivational and cognitive functions
- PD patients various functional deficits have non-overlapping pathologies and can differ in severity
- drugs optimized for motor function, also improve motivational and cognitive functions, but impair other
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SUMMARY
- Only ep memories of long term adaptive value are woth storing
- D3 inhibitory activity can be seen an important gate-keeper to ep memory entering LTM
- D3 becomes active if events are of motivational significance
- D3 inhibits background dopamine chatter
- Paving the way for re-focusing of dopamine resources into forming and consolifating memories that are of motivational and adaptive significance
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