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RECEP AND RECIEVE (automatic nervous system, all drugs mentioned)…

- - - - Alpha 1
      - Alpha 2
    - - Beta 1
        
        Found at heart & kidney
        
        Responsible for:
        -increase cardiac output
        -muscle contraction
        -increased heart rate
        
        Agonists:
        
        Antagonists:
        -Nebivolol
      - Beta 2
        
        Found at:
        -lungs (bronchi)
        -blood vessels (smooth muscle)
        -GI tract
        -bladder
        -uterus
        -liver
        
        Responsible for:
        -smooth muscle relaxation
        -bronchidilation
        -vascodilation
        
        Agonist:
        -Salbutamol
      - Beta 3
      - Beta 4
      - Propanolol
        
        Non selective beta antagonist
        
        Relatives include:
        -
        
        Causes bronchoconstriction
      - Ephedrine
        
        Indirectly acting beta agonist
    - - 80% during signal
      - Both are non selective adregenic receptor agonists
    - - 20% during signal
      - Almost exactly the same as ephinephrine chemically, but lacks a methyl group that ephinephrine see the diff
- - - - Slow (hours to days)
    - - Liphopilic ligands such as steroid enters the cell and through the bilayer membrane
        
        Enters cytoplasm and bind and activates receptor in cytoplasm and nucleus
        -Activated receptor regulates transcription of DNA and therefore protein synthesis
  - - - Nicotinic Ach Receptor, GABA-Benzodiapine receptor
- - - - Agonist::
        
        Nicotine
        
        causes muscles contraction
      - Antagonist:
        
        Curare
        
        causes asphyxiation (deprived of O2) which can lead to death
        
        over relaxation of muscles = paralysis
        
        causes muscle relaxation
      - Found in
        
        neuromuscular junctions in skeletal muscles
      - Are ionotropic/ligan gated receptors
    - - M2
      - M3
        
        Found at smooth muscles except the heart
        
        Responsible for dilation & constriction
        
        Dilation at sphincter(?)
        
        Constriction at bronchi
        
        Vasodilation in blood vessel --> dilation of blood vessel lead to low blood pressure
      - M1
      - Ipratropium (bromide)
        
        Non selective muscarinic Ach receptor antagonist
        
        Causes bronchodilation
      - Are G-protein coupled receptors
      - Pilocarpine
        
        Non selective muscarinic Ach receptor agonist
        
        Used to treat open/closed angle glaucoma
        
        Causes the iris sphincter/ciliary muscle to contract
      - M4
      - M5
      - Atropine (belladona alkaloid)
        
        Non selective muscarinic Ach receptor
        
        competitive, reversible antagonist
      - Carbachol
        
        Muscarinic Ach receptor agonist
        
        Causes smooth muscle contraction
    - - Indirect cholinomimetic
      - Reversible cholinsterase inhibitor
      - How it works:
        -
- - - - Selective H1 receptor antagonist/inverse agonist
      - Prevents smooth muscle contraction
      - anti-histamine! remember ppp!
        
        Non-sedative
    - - Sedative
      - Selective H1 receptor antagonist/inverse agonist
      - Prevents smooth muscle contraction
    - - Sedative
      - H1 receptor antagonist