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Adrenal Endocrine Pathology (CORTEX (Hypercortism - CUSHING SYNDROME…

- - - - clinical features
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      - Destruction of the adrenal cortex
        
        Impaired Glucocortiod,, Mineralocorticoid and sex steroid production DHEA
  - - - Decreased Cortisol
        
        Protein Synthesis
        
        Host Response to infection
        Lymphocyte Transformation
        
        Delayed Hypersensitivity
        
        Circulating Lymphocytes
        
        Circulating Eosinophils
      - Increased Corisol
        
        Gluconeogenisis
        
        Glycogen Deposition
        *Prorein Catabolism --> Muscle weakness
        
        Fat deposition -Centralised obesity and buffulo hump
        
        Sodium Retention
        
        Potassium Loss
        
        Free Water Clearance
        
        Uric Acid Production
        
        Circulating Neurtophils
    - - ACTH Dependant
        
        Increase ACTH from Pituitary
        
        ACTH from Small Cell carcinoma
        
        ACTH Adenoma
        
        ACTH Administration
        
        Increase ACTH from pituitary
        
        Increase Cortisol Release
      - ACTH Independent
        
        Adrenal Adenoma ( secreting cortisol)
        
        Adrenal Carcinoma
        
        Glucocorticoid Administration ( Steroids)
        
        Alcohol induced Pseudo-cushings.
        
        Spontaneous uncontrolled release of cortisol