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Molecular and cellular Components Involved in Pre-metastatic Niche…
Molecular and cellular Components Involved in Pre-metastatic Niche Formation
Tumor-derived
metastasis mouse model
Lung
VEGF
recruits VEGFR1+ BMDCs to the lung
for niche formation (2005)
PIGF
recruits VEGFR1+ BMDCs to the lung; redirects cancer cell metastasis to the pre-metastatic niche (2005)
S100A8/S100A9
recruits Mac1+ myeloid cells and cancer
cells to the inflammatory niche (2008)
versican
enhances metastatic LLC cancer cell growth and promotes inflammatory niche formation via the TLR2 pathway (2009)
melanoma
VEGF
recruits VEGFR1+ BMDCs to the lung
for niche formation (2005)
PIGF
recruits VEGFR1+ BMDCs to the lung; redirects cancer cell metastasis to the pre-metastatic niche (2005)
CD146
promotes CD146+ melanoma cell extravasation and interaction with resident MSC/pericytes for niche formation (2016)
colon
TIMP-1
creates a liver pre-metastatic niche and
drives cancer cell homing to the liver (2015)
Breast
TIMP-1
creates a liver pre-metastatic niche and
drives cancer cell homing to the liver (2015)
Osteogenic N-cadherin
promotes bone micrometastases and tumor
cell proliferation in the niche
tumor microvesical OPN
mobilizes several types of BMDCs for niche
formation; promotes breast cancer cell colonization
and metastatic growth
tumor exosomal microRNA-122
reprograms glucose metabolism in the niche; facilitates metastasis by increasing nutrient availability in the niche
P2Y2R
mediates LOX secretion, collagen crosslinking,
and the recruitment of CD11b+ BMDCs to the
pre-metastatic lung
Pancreatic
CD44/CD44v6
regulates cancer stem cell behavior and allows exosomes to modulate niche cells for cancer cell embedding and growth (2009/2013)
tumor exosomal MIF
recruits macrophages to the liver premetastatic niche and induces fibronectin via TGF for niche formation (2015)
Gastric
CD44/CD44v6
regulates cancer stem cell behavior and allows exosomes to modulate niche cells for cancer cell embedding and growth (2009/2013)
prostate
tumor large oncosome miR-1227
induces the migration of CAFs to promote
tumor metastasis
Glioblastoma
tumor large oncosome miR-1227
induces the migration of CAFs to promote
tumor metastasis
Stroma-derived
metastasis mouse model
Breast
endothelial cell/ ANG-2
recruits macrophages and induces inflammatory, angiogenic response of endothelial cells for niche formation
microvascular endothelial cell/ PGE2
recruits BMDCs for lung niche formation and enhances the adhesion of cancer cells to the lung niche
endothelial cell/ periostin
creates an immunosuppressive niche and promotes breast cancer cell outgrowth within the niche
CAFs/HSF1
reprograms CAFs and cancer cells via TGF-b and SDF-1 signaling to promote tumor metastasis into the niche
astrocyte exosomal miR-19a
silences PTEN to increase CCL2 to recruit myeloid cells into the niche; enhances brain metastatic cancer cell outgrowth in the niche
MSC exosomal miR-23b
induces breast cancer cell dormancy in metastatic niche through the suppression of target gene MARCKS
Lung
endothelial cell/ ANG-2
recruits macrophages and induces inflammatory, angiogenic response of endothelial cells for niche formation
fibroblasts/ fibronectin
determines the location of niche formation by recruiting VLA-4+ BMDCs; increases metastatic seeding of CTCs
CAFs/girdin
promotes ECM remodeling for niche formation
and promotes tumor growth
Melanoma
fibroblasts/ fibronectin
determines the location of niche formation by recruiting VLA-4+ BMDCs; increases metastatic seeding of CTCs
astrocyte exosomal miR-19a
silences PTEN to increase CCL2 to recruit myeloid cells into the niche; enhances brain metastatic cancer cell outgrowth in the niche
Tumor/Stroma-derived
metastasis mouse model
Lung
TGF-b
induces lung expression of S100A8/S100A9, SAA3 to develop an inflammatory niche; remodels lung parenchyma for niche formation; accumulates TAMs and Treg cells in the niche
TNF-a
induces lung expression of S100A8/S100A9, SAA3
and remodels lung parenchyma for niche formation
G-CSF
mobilizes MDSCs to the lung niche and promotes
metastatic cancer cell seeding in the lung
MMPs
promotes ECM degradation and tissue remodeling for niche formation; promotes metastatic cancer cell outgrowth in the niche
Melanoma
TGF-b
induces lung expression of S100A8/S100A9, SAA3 to develop an inflammatory niche; remodels lung parenchyma for niche formation; accumulates TAMs and Treg cells in the niche
TNF-a
induces lung expression of S100A8/S100A9, SAA3
and remodels lung parenchyma for niche formation
G-CSF
mobilizes MDSCs to the lung niche and promotes
metastatic cancer cell seeding in the lung
MCP-1/CCL2
recruits monocytes and BMDCs for niche formation; enhances the extravasation of the cancer cells via VEGF; promotes metastatic cancer cell outgrowth in brain niche
MMPs
promotes ECM degradation and tissue remodeling for niche formation; promotes metastatic cancer cell outgrowth in the niche
Breast
G-CSF
mobilizes MDSCs to the lung niche and promotes
metastatic cancer cell seeding in the lung
SDF-1/CXCL12
recruits VEGFR1+ and CD11b+ BMDCs to the niche; regulates angiogenesis in the niche; promotes the outgrowth of CXCR4-expressing cancer cells in the pre-metastatic niche
MCP-1/CCL2
recruits monocytes and BMDCs for niche formation; enhances the extravasation of the cancer cells via VEGF; promotes metastatic cancer cell outgrowth in brain niche
LOX
promotes ECM remodeling and recruits CD11b+ cells for
niche formation; enhances colonization of CTCs to the niche
microvesical PDGF
mediates crosstalk between cancer cells and endothelial cells to promote the formation of a prometastatic vascular niche through Arf6 upregulation; promotes the angiogenic switch
Colon
SDF-1/CXCL12
recruits VEGFR1+ and CD11b+ BMDCs to the niche; regulates angiogenesis in the niche; promotes the outgrowth of CXCR4-expressing cancer cells in the pre-metastatic niche
Glioblastoma
HIFs
recruits BMDCs to promote angiogenesis; induces
arginase and NO to support cancer cell invasion
Ovarian
microvesical PDGF
mediates crosstalk between cancer cells and endothelial cells to promote the formation of a prometastatic vascular niche through Arf6 upregulation; promotes the angiogenic switch
Prostate
RANK/RANKL
promotes niche formation via a RANKL/c-Met feedforward
loop; reprograms tumor cells for bone colonization
BMDC-derived
metastasis mouse model
Lung
VLA-4
allows adhesion of the BMDCs in the pre-metastatic lung to
provide a permissive niche for the incoming cancer cells
Id3
facilitates the mobilization of VEGFR1+ cells to the niche
Melanoma
VLA-4
allows adhesion of the BMDCs in the pre-metastatic lung to
provide a permissive niche for the incoming cancer cells
Id3
facilitates the mobilization of VEGFR1+ cells to the niche
Others
metastasis mouse model
Lung
Platelet P2Y12
recruits VEGFR1+ BMDCs and increases ECM fibronectin
deposition in the lung pre-metastatic niche
Melanoma
Platelet P2Y12
recruits VEGFR1+ BMDCs and increases ECM fibronectin
deposition in the lung pre-metastatic niche