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Bleeding Disorders (Couglation Factor (HemoPhillia (X-linked Ressive…

- - - - Externsic Pathway ( Factor 7 ) and the Common Pathway
    - - Externsic Pathway ( Factor8,9,11,12
        ) and the Common Pathway
  - - - Haemophilic Male → 100% carrier daughters , boys all normal
      - Carrier Female → 50% carrier female, 50% Haemophilic male
    - - Factor 8 Defiency
    - - Factor 9 Defiency
  - - - Vtiamin K Factors affected ( 1972 )
      - Pt affected ( INR )
    - - Affect Anti-Thrombin
      - Ptt affected ( tt like H )
  - - - activation of Couglation Factors
        
        Thrombosis
      - Activation of Fibronlytic Pathway
    - - Most Common Cause Gram Negtaive Sepsis
      - Obestritic
      - Malignancy