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STEM CELLS (APPLICATION (BM transplant (Adult stem cells
found in…
STEM CELLS
APPLICATION
BM transplant
- Adult stem cells
- found in spongy bone where blood cells form.
- used to replace damaged or destroyed BM with healthy BM stem cells.
- ttt pt with leukemia, aplastic anemia, lymphomas.
- Procedure:
- Tissue matching
- extraction of BM from donor pelvis.
- Recepient undergo chemo--destroy all malignant blood cells.
- filter donor's marrow to increase ratio of stem cells.
- IV transfusion to recepient.*
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heart muscle
useful to study how heart works, can genetically manipulate the cells to study how disease develop, and for drug screening in pharmaceutical development/
Heart Disease
inject adult BM stem cells into the heart--> believed to improve cardiac function in HF or heart attack pt.
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type 1 DM
pancreatic cells do not produce insulin. Embryonic stem cells might be trained to become pancreatic islets cells
Drug delivery to brain
used in brain disorders. harvest neural stem cells from patient's brain, coaxed to proliferate outside, genetically engineered, then re-implanted to deliver a drug that normally cannot pass BBB.
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BIODATA
Definition
STEM CELLS
a cell that has the ability to continuously divide and differentiate (develop) into various other kinds of cells/tissues
-->allow them to replace death cells, defective cells/tissues in diseased patients.
Adult stem Cells
=undifferentiated cells found among specialized or differentiated cells in a tissue or organ after birth
eg: skin, fat cells, BM, brain
Embryonic Germ Cells
=derived from part of human embryo or fetus that will ultimately produce eggs or sperms(gametes)
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Types
Totipotent
Early embryos cells (D1-D3)
can develop into a complete new organism/individual (identical twins)
ICSI use this
Pluripotent
Undiff. inner cell mass of blastocyst (D5-D14)
can form any of over 200 different cell types found in the body, except placenta and extra-embryonic tissues
Multipotent
Derived from fetal tissue, cord blood, adult stem cells, tissue specific stem cells, (D14 and beyond)
can form a number of other tissues (limited differentiation)
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Indications
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Future
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Brain & Sp. cord injury, etc
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