Please enable JavaScript.
Coggle requires JavaScript to display documents.
Factors Affecting Synaptic Transmission (Internal enviromental changes…
Factors Affecting Synaptic Transmission
Diseases
Tetanus Toxin
CAUSE
SPASTIC
PARALYSIS
Spasm
lower jaw
Respiratory muscle :arrow_right: Death
Block release of
GAB
A
Botulism toxin
Lead to
Flaccid
Paralysis
BOTOX
effictive in treatment of Muscle Spasm
Removes wrinkles ( in facial Muscles)
Block release
Ach
Mechanism
: Interfere with Snare ptn. blocking transmitters release
Internal enviromental changes
HypoGlycemia
Effect
:inhibit synaptic transmission
Cause:
: glucose is the fuel of Brain
HypoCalcemia*
Effect
: facilitate synaptic transmission & :arrow_double_up: postsynaptic potemital which may lead to tetany
Cause
: decrease ionized Ca++
PH
Acidosis
Cause
: increased Ionized Ca++
Clinical
:Coma in DM II
Effect
:decrease synaptic transmission
Alkalosis
Cause:
:Decrease in ionized Ca++
Clinical
:if epiletic patient hyperventlation this may cause convulsions
Effect
:Increase excitability of Neurins and increase synaptic transmitters
Hypoxia
Effect
: Inhibit transmission Temporary or prolonged which lead to death
Cause
: Synaptic transmission depend on adqucate oxygenation
Drugs
Analgesics&Hypnotics&anaesthetics
:arrow_right:stablize cell mebrane causing hyperpolarization ... interfere reuptake and synthesis and release of certin Neurotransmitters
Strychnine :
Competes with inhibitory Neurotransmitter ..l
eaving the Exitatory
pathway which lead to convulsion.. muscle spasm .. Death
Thiophylline & Thioboramine& caffine
:arrow_right: Facilitation