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Synaptic Plasticity (Long Term Form (LTP (Def :Persistance enhancement of…
Synaptic Plasticity
Long Term Form
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LTP
Def :Persistance enhancement of postsynaptic after repeated stimulation of presynaptic ( like PTP but Prolonged)
Ionic Basis : Increasing intracellular Ca++ in postsynapstic rather than presynaptic :
1-Gluatmate released from Presynaptic bind to AMPA & NMDA in postsynaptic.
2-Activation of AMBA relief Mg++Block in NMDA receptor channel
3-Ca++ enters with Na+
4- :arrow_double_up: Ca++ activate activate Ca++ calmodulin :arrow_right: activate Calmudolin kinase II
5-KInase phosphorylase AMPA receptor lead to Increasing its conductance and moving it into postsynaptic membrane
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Short Term form
Habituation
Ionic Basis:Gradual Inactivation of Ca++ channels decrease release of Neurotransmitters from Presynaptic
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PTP
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Def : Breif Tetanizing train of impulses to presynaptic N. lead to Continous discharge from postsynaptic N. After stimuls stoppage
Def: Ability of change in Function to achive a demand synaptic transmission can be strenghted orweakned for short or long time .
Importance : represent forms of learning and memory
Notice : LTP & Long term depression are both in Hippocampal