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36-year old female lawyer with diabetes mellitus (Disease of exocrine…
36-year old female lawyer with diabetes mellitus
Type I diabetes
(beta cell destruction, leading to absolute insulin deficiency): associates with DKA;
common in <65 patients
Idiopathic
Immune-mediated
Type II diabetics
(insulin resistance)
Disease of exocrine pancreas
Pancreatitis
Pancreatectomy
Neoplastic
Cystic fibrosis
Hereditary hemochromatosis
Fibrocalculous pancreatopathy
Genetic linkage:
Mutations in carboxyl ester lipase
Endocrinopathies
Hyperthyroidism
Acromegaly
Cushing's syndrome
Glucagonoma
Pheochromocytoma
Aldosteronoma
Somatostatinoma
Drug or chemical-induced
Infections
Congenital rubella
CMV
Coxsackievirus
Gestational
DM
Genetic defects in insulin action
Genetic defects of beta cell development or function
Maturity onset diabetes of the young (MODY): applicable < 25 years old
Uncommon immune-mediated diabetes
"Stiff man" syndrome
Anti-insulin receptor antibodies