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BD TLEAD 13 (Anemia) (RBC Decreased Production (Production Defect)…

- - - - Isolated decreased RBC
        
        Renal dysfunction
        
        Chronic Inflammation Anemia (e.g. RA, extensive trauma, connective tissue disorders, chronic infection)
        
        Pure Red Cell Aplasia (PRCA)
      - Pancytopenia
        
        Marrow infiltration (MDS or Malignancy e.g. Leukemia, lymphoma)
        
        Aplastic Anemia
  - - - Liver dysfunction, alcohol, drugs
      - Hypothyroidism
      - B12 / Folate deficiency (due to pernicious anemia or malabsorptive causes such as Crohn's, Coeliac disease & SBS)
    - - Iron deficiency
      - Thalassemia
      - Sideroblastic anemia
- - - - Metabolism
        
        G6PD deficiency
        
        Pyruvate kinase deficiency
      - Haemoglobin
        
        Thalassemia
        
        Sickle Cell
      - Membrane
        
        Spherocytosis
        
        Elliptocytosis
    - - Non-immune
        
        Disseminated intravascular coagulation (DIC)
        
        Prosthetic Valves (anemia is a complication)
        
        Infection
        
        Hypersplenism
      - Immune
        
        Autoimmune (e.g. Warm/Cold AIHA)
        
        Alloimmune / Isoimmune (e.g. Rhesus or ABO incompability in transfusion rxn)
        
        Drugs (e.g. NSAIDs, methotrexate, azathioprine,