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Pathway to cell proliferation/ overcoming the G1 - S checkpoint (Growth…
Pathway to cell proliferation/ overcoming the G1 - S checkpoint
Growth factor binds GRB2
RasGEF activated
Ras Activated
Recruits Myc
Myc (TF) Activated
activated by beta catenin
Myc transcribes Cyclin D
Cyclin D recruits CDK4
Cyclin D/CDK4 phosphorylates RB1
RB1 Releases E2F
E2F Activated
E2f transcribes Cyclin E
1 more item...
Phosphorylates Ras
Hypoxia or Over proliferation or DNA damage or Telomeric shortening
p53 Activated
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p21 transcribed
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DNA damage repaired
MDM2 transcribed
p14ARF
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p16INK4
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p27
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Nf1 (RasGAP)
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APC phosphorylates beta catenin targeting him for degradation
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