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Na+ Reabsorbtion (Reabsorbtion from PCT 65% (At basolateral Border…
Na+ Reabsorbtion
occur by 99% to 96%
Accompained by reabsorbtion of Solutes and H2o and H+ secretion and HCo3- reabsorbtion
Reabsorbtion from PCT
65%
At basolateral Border
crating negtive potential inside the cell
low intracellular Na+ conc.
Na+leave the cell via
Na+/k+ Atpbase
At Luminal Border
by
diffusion
No Tm ... Obey Gradient time transport as transport rate at basolateral border is more than luminalr boeder
Absorbtion of Solute in First half
Counter Transport
Na+-H+ Exchange
CoTransport
Amino acids
Sulphate and Pi
Glucose
K
HCO3-
Absorbtion of Solute in late half
CL-
Reabsorbtion From Loop of Henel
Thin Ascending
absorbtion of NaCl is
Passive
Thick Ascending
Most of K+
Reflux
back to Lumen via k+ channels
This ensure presnce of sufficient K+ for the transporter
resulting Positive potential Facilitate paracellular absorbtion of serval cations k+-Na+-Ca++-Mg++
Carrier for Na+- K+- 2Cl-
25% by Cotransporter
Barret Syndrome
: Defect in the Crreir :arrow_right: Na+ loss - hypo volume depletion - Hypercalcemia - Hypokalemia - Alkalosis
Descending
No Reabsorbtion
DCT
Early Part
Reabsorbtion of Na Cl
Late Part and Collecting duct
(<10%)
Principle cells
Na+ leave the cell via ATP base in baso lateral border
Na+ accompained with Cl- reabsorbtion
Na+ into via channels in apical membrane
Cl- reabsorbtion is Paracellular
Reabsortion of Na+ in exchange for K+