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IgA Nephropathy ( Berger's) (HSP (connective tissue, scrotum, skin,…
IgA Nephropathy ( Berger's)
IgA1 (galactose deficient) - not identified by body and therefor not degraded. Accumulate. IgG binds to IgA( galactose deficient). Type III hypersens. complxes deposit in mesangium. activates alternative complement pathway. glomerular injury
Nephritic: haematuria
Childhood: microscopic or gross haematuria
Decades--> renal failure
develops during infection of mucosal lining. GI, resp
light microscopy: mesangial proliferation
electron: immune deposits in mesangium
immunofluoresence: +ve IgA (differentiates)
HSP
connective tissue
scrotum
skin
joints
kidneys
GI tract
Tx: to prevent further damage and end stage kidney disease
eat well, reduce salt and cholesterol
anti bp meds
corticosteroids
IgA is just kidney