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Focal Segmental Glomerulosclerosis (secondary (clear underlying cause)…
Focal Segmental Glomerulosclerosis
scar tissue in glomeruli, only part of the glomeruli and only some of all in kidney.
Nephrotic syndrome
primary FSGS. idiopathic
podocytes damaged.
#
carrying on from minimal chnage theory.
hyalinosis (trapped particles)
then sclerosis
secondary (clear underlying cause)
Sickle cell (ischaemia)
HIV (HIV assoc nephropathy)
Heroin abuse (heroin nephropathy)
kidney hyperperfusion
increased pressure in glom capillaries
Histology
segmental slcerosis and hyalinosis
electron microscope
effacement of foot processes
immunofluorescence, there
might
be non-spec focal deposits of IgM and complement
most common cause of nephrotic in African Americans and hispanics
Treat with steroids - inconsistent response may cause renal failure.