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Immunology (Adaptive immunity APC (macrophages, dendritic cells and B…

- - - - CD4+, protein CD4
        MHC 2
    - - MHC 1
        not soluble
        IL2 required
        
        Once active, release molecules granzymes or perforins
        
        perforins cause holes: osmollyse
        
        Granzyme causes target cell to apoptose
  - - - Dicrect microbe interaction with complement protein
    - - Antigen antibody complex
  - - - Antibody: humoral
        
        Opsonisation (encourage phagocytosis): they clump around pathogen/anchor it
        
        Activate complement (classic pathway)
        
        Reduce toxity
        
        IgD
        
        Indiviudlal molecule surface B cells
        
        Bind antigens in ECF
        
        Sensilization of B cell
        
        IgM
        
        Pentameric structure
        
        Antibody secreted aftet antigen encountered
        
        IgM declines as IgG accelerates
        
        agglutination of incompatible bloody types are IgM antibodies
        
        IgE
        
        indiviudal molecule to exposed surfaces of basophils and mast cells
        
        IgA
        
        Dimer/trimer
        
        Glandular secretion mucus, tears, saliva and semen
        
        Antibodies attack pathogens before they gain access to internal tissues
        
        IgG
        
        Account for 80% antibodies
        
        Resistance against many virsues, bacteria and bacterial toxins
- - - - T helper cell binds to MHC2 antigen complex. T helper cell produces cytokine (IL2)
        
        Inititates proliferation/maturation B cells
        
        Most into plasma cells, some into memory cells