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CBL 2 (Which three major parts of the brain are implicated in higher motor…
CBL 2
- Which three major parts of the brain are implicated in higher motor control?
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- What do we call abnormal slowing of movement?
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- Explain the role of the neurotransmitter dopamine in the control of movement?
- Nuerons secrete dopamine basal ganglia
- Not enough: voluntary muscles delayed/uncoordinated
- Too much = unnecessary movement
- Messages to nucleus accumbens
Excitatory D1: direct
Inhibitory D2: inihibtory
- What type of neurotransmitter is dopamine, and which other molecules are
included in this family? List some of their functions.
- Inhibitory
- monoamine, catecholamines: motivation + addiction
- Others include: Epinephrine and norepinephrine (sympathetic NS)
- Are there any features to suggest altered motor control other than the slowed
limb movements?
Reduced, facial expression, little spontaneous speech, stiff limbs and leg spasms
- Which disease most commonly causes slowing of movement, and why is this case
unusual?
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- What is the father’s significance?
Some faulty genes can cause Parkinson's:
LRRK2, PARK 7, PINK1, PRKN, SNCA