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Cancer (Risk factors for cancer (Risk Factors for cancer (Many can have at…

- - - - Chronic inflammation (precancer ,linked to 20% of total cancer)
        
        Environment created by the immune system in response to a foreign body in the body
        
        Infecction Bacteria(virus)
        a)Heliobactor Plylori
        
        Immune deregulation (Self attacking immune system)
        a) Inflammatory bowl disease,
        b) Autoimmune hepatitis
        
        Environmental exposure-particulate from tobacco , asbestos,silica
      - Post-Tumor development- Inflammatory environment created around tumor after it has formed
        
        Production of attractant chemical by cancer to attract inflammatory cells
        
        Production of inflammatory molecules by cancer cells and inflammatory cells to increase cancer growth and survival
        
        Cell death at tumor core(absence of blood supply
      - Post-Treatment inflammation -Environment created by massive cells death (cancer and normal cells) after cancer therapy such as chemo or radiotherapy:
        
        Dead cells and normal cells burst to release all biochemicals into the surrounding ,including inflammatory chemicals
        
        However this may lead to two scenario
        
        Attract immune system to site of destruction for clean up
        
        Release inflammatory chemicals may accelerated growth of residual/surviving tumor cells- therapy resistant cancer
- - - - Cancer cells overdrive this pathway to produce extra energy to divide itself
      - Hide itself form the immune system through the production of the pathway chemicals
      - Kynurenine pathway and cancer- cancer cells has abnormal kynurenine pathway activity elevated production of chemical products