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Henoch-Schonlein Purpura (complications (recurrence, intusussception,…
Henoch-Schonlein Purpura
definition
acute IgA-mediated disorder characterised by a generalised vasculitis involving small vessels of the skin, GI tract, kidneys, joints, and rarely the lungs and CNS
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pathophysiology
IgA aggregates or IgA complexes with complement deposited in target organs, resulting in elaboration of inflammatory mediators, including vascular mediators, including vascular prostaglandins such as prostacyclin, may play a key role
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