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Antipsychotics (1st Generation/ Conventional "NEUROLEPTICS"…
Antipsychotics
1st Generation/ Conventional "NEUROLEPTICS"
Drugs
Haloperidol (Haldol)
Chlorpromazine (Thorazine)
Block receptors for dopamine, ACh, NE, and histamine
Treatment
Schizophrenia
Bipolar disorder- secondary to mood stabilizer
Adverse Effects
Extrapyramidal symptoms
Movement disorders, dystonia, parkinsonism, tardive dyskinesia
Neuroleptic malignant syndrome
Rigidity, fever, sweating, fluctuations in BP/cardiac rhythm
TX of NMS includes Dantrolene (Dantrium)
Anticholinergics Effects
Hypotension
Sedation
2nd Generation
Drugs
Clozapine (Clozaril)
Risperidone (Risperdal)
Olanzapine (Zyprexa)
Blocks serotonin and dopamine receptors
Lower affinity for dopamine
Less extrapyramidal effects
Treatment
Schizophrenia
Adverse Effects
Agranulocytosis
Metabolic side effects
Weight gain
New onset diabetes
Dyslipidemia
Less extrapyramidal side effects