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Sedatives - hypnotics (Benzodiazepines (-azepam or -azolam) (Adverse…

- - - - Amnesia effect
  - - - In pts with liver damage
      - Metabolites are still active
    - - Due to alterations in CNS
      - CNS depression
        
        Promote sleep
        
        Reduce anxiety
        
        Muscle relaxation
        
        Confusion
        
        Amnesia
  - - - Insomnia, excitation, rage
    - - Hypotension
    - - Withdrawal from long term high dose resembles anxiety
        
        Panic, HTN, insomnia, tremors, sweating
        
        Potenitally fatal- can lead to seizures
  - - - Competitive receptor antagonist
      - Blocks CNS effect of benzodiazepine
      - Used for OD
      - Can also be given post-op
- - - - Fatal in OD
      - Often used for suicide
    - - Continued use is required to avoid withdrawal symptoms
      - Abrupt DC can be fatal
    - - When given long term, tolerance to CNS effects can occur
        
        Dose may need to be increased