revision

reeler mice, development of cerebral organs reversed

explain with experimental evidence how the lens of the eye develops

explain fgf signalling in brain development

always use experimental evidence

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isthmus mirror image; what would expect to happen is smaller or loss of polarity

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fgf acts as morphogen in brain patterning

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reeler mice development of cerebral organs; mirror image Gain of function experiment typical of a morphogen

Neural crest cells = cartilage

explain obvious

  • lens placode from surface ectoderm, develops very close to optic cup

ask yourself; if they affect eachother

separate tissues to see if develop individually

graft optic cup elsewhere; historically whereat clean grafts so developed elsewhere

surface ectoderm was sufficient

transcription factor later located pax6 expressed in both knock out experiments done to analyse

look further at this

start with a quick drawing of developing lens thickening of surface ectoderm vs neural ectoderm outcome of brain

strip of ectoderm and stick surface ectoderm into culture alone

gain of function

this develops on its own ask for genes??? #

check gene expressing, gain/ loss of function to check necessary/sufficient = if sufficient lots of little lens like structures