revision
reeler mice, development of cerebral organs reversed
explain with experimental evidence how the lens of the eye develops
explain fgf signalling in brain development
always use experimental evidence
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isthmus mirror image; what would expect to happen is smaller or loss of polarity
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fgf acts as morphogen in brain patterning
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reeler mice development of cerebral organs; mirror image Gain of function experiment typical of a morphogen
Neural crest cells = cartilage
explain obvious
- lens placode from surface ectoderm, develops very close to optic cup
ask yourself; if they affect eachother
separate tissues to see if develop individually
graft optic cup elsewhere; historically whereat clean grafts so developed elsewhere
surface ectoderm was sufficient
transcription factor later located pax6 expressed in both knock out experiments done to analyse
look further at this
start with a quick drawing of developing lens thickening of surface ectoderm vs neural ectoderm outcome of brain
strip of ectoderm and stick surface ectoderm into culture alone
gain of function
this develops on its own ask for genes??? #
check gene expressing, gain/ loss of function to check necessary/sufficient = if sufficient lots of little lens like structures