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Thalassemia (Complications (secondary hemochromatosis (heart failure, due…

- - - - beta-globin tetramers #
  - - - excess beta-globin forms tetramers #
      - incompatible with life
  - - - African
    - - Asian
- - - - marrow expansion
        
        extramedullary hematopoiesis
  - - - minimal F band
      - prominent A band
      - normal/slightly elevated A2
    - - minimal A band
      - normal/slightly elevated A2
      - prominent F band
  - - - small
      - pale
  - - - anisopoikilocytosis #
- - - - mutation in promoter region
        
        still some production #
    - - mutation in splice site/chain termination
        
        no production #
    - - β+/β°
      - β°/β°
        
        most severe
      - β+/β+
        
        mildest
    - - alpha chains #
  - - - β°/β
      - β+/β